Central Synagogue's Sisterhood is a member group of Women of Reform Judaism, the women’s affiliate of URJ. Established in 1913, WRJ now represents more than 75,000 women in over 500 women’s groups in North America and around the world.

Sisterhood's mission is to ensure the future of our synagogue and of Reform Judaism by fundraising and providing the congregation with innovative and spiritual programming. Through the YES Fund (Youth, Education, and Special Projects), Sisterhood, as a member of WRJ, helps to provide financial support to rabbinical students at Hebrew Union College-Jewish Institute of Religion, to the youth programs of the Reform Movement, and to programs benefiting women and children in Israel and the former Soviet Union.